Thermal Performance Simulation of an LTCC Micro-Reactor for RT-PCR in Detection of SARS-Cov-2 Detection


  • Lokesh Kulhari Karnataka Hybrid Micro device Pvt Ltd, Bangalore, Karnataka 560100, India
  • Nikhil Suri CSIR- Central Electronics Engineering Research Institute, Pilani, India- 333031, India
  • Badrul Hisham Ahmad Faculty of Electronic and Computer Engineering, Universiti Teknikal Malaysia Melaka, Melaka, Malaysia
  • Preecha Yupapin Department of Electrical Technology, School of Industrial Technology, Institute of Vocational Education Northeastern 2, Sakonnakhorn 47000, Thailand
  • Kanad Ray AMITY University Rajasthan, Jaipur, Rajasthan 303002, India



LTCC, Micro-reactor, COVID-19, Polymerase chain reaction


In present paper, thermal simulation of LTCC based micro-chamber has been performed which is a key part of RT-PCR device. The RT-PCR device plays an important role in SARS-CoV-2 testing. The rRT-PCR system requires three different thermal cycles for DNA amplification which takes part in detection of SARS-CoV-2. The thermal cycle can be equipped using a heater structure in the chamber. A new LTCC based technique to develop micro-chamber has been designed and simulation has been performed using COMSOL to optimize thermal properties. Temperature distribution for  a micro-chamber at three different voltages has been simulated. The temperature distribution is more uniform in  micro-chamber with a buried metallic layer in comparision to micro-chamber without a metallic layer. The heater and temperature sensor were located outside the reaction chamber. A platinum based pattern as PTC temperature sensor is used in temperature measurement.




How to Cite

Kulhari, L. ., Suri, N. ., Ahmad, B. H. ., Yupapin, P. ., & Ray, K. . (2022). Thermal Performance Simulation of an LTCC Micro-Reactor for RT-PCR in Detection of SARS-Cov-2 Detection. Journal of Telecommunication, Electronic and Computer Engineering (JTEC), 14(3), 29–34.

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