Model of Hyperthermia Therapy in Melanoma Treatment: Comparison between Constant and Temperature Dependent Blood Perfusion Rate

Abstract

This work deals with the modeling of hyperthermia therapy for melanoma skin cancer by considering 3D nonlinear Pennesbioheat transfer equation with Temperature Dependent Blood Perfusion Rate (TDBPR). The proposed model consists of a five-layer biological skin medium with third stage melanoma tumor utilizing each layer by Pennesbioheat equation. A Finite Element Analysis (FEA) in bioheat transfer model is employed and the result of nonlinear model in the time domains is solved using COMSOL Multiphysics. The variables of heat fluxes as control variables were applied to the proposed model for verification and assessing its applicability and effectiveness. The simulation output shows that the proposed model is valid under our test variable. This proposed model is used to easily and accurately study the thermal behavior of the biological skin during hyperthermia treatment procedure.