Reconstruction of Cortical and Cancellous Bone in Tibia with Osteogenesis Imperfecta
Keywords:Cortical, Cancellous, Finite Element, Osteogenesis Imperfecta, Stress Distribution, Tibia,
AbstractOsteogenesis Imperfecta (OI) is the bone fragility disorder that leads to long bone bowing. Finite Element Analysis (FEA) has become the tool of choice to assess behaviour structural within bones. Currently, the FEA performed on the tibia is based on the bone constructed without considering different components of the bone, where the bone was created as a single material. In an attempt to further investigate the bone with OI, the present study was conducted to investigate the mechanical stress distribution using finite element model of the OI affected tibia. The model was reconstructed from the CT images composed of cortical and cancellous bones obtained from Osirix database. The segmentation of the cortical and cancellous of the tibia was performed on 346 images using two different methods which are global thresholding and the selection of the binary object. The segmented images were used to develop a three-dimensional model of the tibia using VOXELCON software. The boundary conditions were set to the meshed model in preparation for the finite element analysis using the same software. Displacements ranging from 5 mm to 35 mm were assigned to a point in between the proximal and distal of the tibia model. In the coronal plane, the highest stress levels were recorded on the medial side of the cortical bone, whereas in the sagittal plane, the highest stress levels were recorded on the anterior side of the cortical bone when the model was subjected to 35 mm displacement. The cancellous bone, however, showed lower stress levels on both planes when subjected to similar displacement. With each increment of displacement, the model experienced more stress and caused the higher percentage volume of individual cortical and cancellous that exceed critical stress of 115 MPa. There were no significant differences in the percentage volume of voxels affected between the cortical and cancellous bones for both coronal and sagittal planes with the pvalue of 0.29 and 0.32 respectively (p > 0.05). There was no significant difference obtained for the percentage volume of voxels affected between the coronal and sagittal planes with the p-value is 0.13 (p > 0.05).
C. Caouette et al., “Biomechanical analysis of fracture risk associated with tibia deformity in children with osteogenesis imperfecta: a finite element analysis,” J. Musculoskelet. Neuronal Interact, vol. 14, no. 2, pp. 205–12, 2014.
C. Caouette, N. Ikin, I. Villemure, P. J. Arnoux, F. Rauch, and C. É. Aubin, “Geometry reconstruction method for patient-specific finite element models for the assessment of tibia fracture risk in osteogenesis imperfecta,” Med. Biol. Eng. Comput., pp. 1–12, 2016.
K. Rathnayaka, T. Sahama, M. A. Schuetz, and B. Schmutz, “Effects of CT image segmentation methods on the accuracy of long bone 3D reconstructions,” Med. Eng. Phys., vol. 33, no. 2, pp. 226–233, 2011.
Y. Zhang, Z. He, S. Fan, K. He, and C. Li, “Automatic Thresholding of micro-CT trabecular bone images,” in Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, Sanya, China, 2008, vol. 2, pp. 23–27.
D. L. Pham, C. Xu, and J. L. Prince, “Current methods in medical image segmentation,” Annu. Rev. Biomed. Eng., vol. 2, no. 1, pp. 315-337, 2000.
E. Cendre, V. Kaftandjian, G. Peix, M. Jourlin, and D. Babot, “An investigation of segmentation methods and texture analysis applied to tomographic images of human vertebral cancellous bone,” J. Microsc., vol. 197, no. 3, pp. 305–316, 2000.
G. Rizzo, D. Tresoldi, E. Scalco, M. Mendez, A. M. Bianchi, and A. Rubinacci, “Automatic Segmentation of Cortical and Trabecular Components of Bone Specimens Acquired by pQCT,” in 30th Annual International Conference of the IEEE EMBS, Vancouver, Canada, 2008, pp. 486–489.
F. Gelaude, J. Vander Sloten, and B. Lauwers, “Semi-automated segmentation and visualisation of outer bone cortex from medical images,” Comput. Methods Biomech. Biomed. Engin., vol. 9, no. 1, pp. 65–77, 2006.
Z. Fan, P. Smith, E.C. Eckstein and G.F. Harris, “Mechanical properties of OI Type III human bone tissue measured by nano indentation,” J. Biomed. Mater. Res., vol. 79A, pp. 71–77, 2006.
Z. F. Fan, P. Smith, F. Rauch, and G. F. Harris, “Nano indentation as a means for distinguishing clinical type of osteogenesis imperfecta,” Compos. Part B Eng., vol. 38, no. 3, pp. 411–415, 2007.
Z. Fan, P. a Smith, G. F. Harris, and F. Rauch, “Comparison of Nano indentation Measurements between Osteogenesis Imperfecta Type III and Type IV and Between Different Anatomic Locations (Femur / Tibia versus Iliac Crest),” Connect. Tissue Res., vol. 48, pp. 70–75, 2007.
J. M. Fritz, Y. Guan, M. Wang, P. A. Smith, and G. F. Harris, “A fracture risk assessment model of the femur in children with osteogenesis imperfecta ( OI ) during gait,” Med. Eng. Phys., vol. 31, pp. 1043–1048, 2009.
C. Albert, J. Jameson, P. Smith, and G. Harris, “Reduced diaphyseal strength associated with high intracortical vascular porosity within long bones of children with osteogenesis imperfecta,” Bone, vol. 66, pp. 121–130, 2014.
“OsiriX | DICOM Image Library.” [Online]. Available: http://www.osirix-viewer.com/resources/dicom-image-library/. [Accessed: 15-May-2017].
J. Fritz, N. Grosland, P. Smith, and G. Harris, “Improved mesh for a finite element model of fracture risk assessment in Oseogenesis Imperfecta,” 35th Annual Conference of the American Society of Biomechanics, Long Beach, 2011.
Z. Fan, P. Smith, K. Reiners, and S. Hassani, “Biomechanics of Femoral Deformity in Osteogenesis Imperfecta (OI): A Quantitative Approach to Rehabilitation,” in Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, 2004, pp. 4884–4887.
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